Preoperative Administration of Parecoxib for Postoperative Pain Management in Cervical Laminoplasty: A Retrospective Study

Xing Guo1,2#, Rui Zhao1,2#, Jiaming Zhou1,2 and Yuan Xue1,2*

1 Department of Orthopedic Surgery, Tianjin Medical University General Hospital, China 2 Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China # These authors contributed equally to this work

^*Correspondance to: Yuan Xue 

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Abstract:

Poor postoperative pain control impairs patient recovery and lengthens the duration of hospitalization after various surgeries. Parecoxib has been proved to be effective in various minor surgeries. However, despite the extensive use of parecoxib, there is still a gap for applying parecoxib in the major surgeries like cervical laminoplasty. This study aimed to investigate the efficacy of preoperative administration of parecoxib for postoperative pain control after cervical laminoplasty. In total, 114 patients undergoing cervical laminoplasty were included for retrospective review and divided into parecoxib and control groups. The Visual Analogue Scale (VAS) score, postoperative morphine consumption, operative indexes (operative duration, intraoperative blood loss volume and incision length), hospitalization duration and incidence of complications were analyzed. There was no significant difference in demographic (gender, age and BMI etc.) and operative indexes between the two groups. The VAS score in parecoxib group of 4, 8, 12 and 24 h postoperatively were significantly lower relative to the control group (P<0.001). The morphine consumption in the parecoxib group was also less than the control group in each time point postoperatively (P<0.001). Parecoxib group exhibited significantly shorter total hospitalization duration (11.2 ± 13.9 days) than the control group (12.6 ± 3.1 days, P=0.028). Significant differences were also observed in the postoperative hospitalization duration between the parecoxib and control groups (P=0.004). There was no significant difference in complications between the two groups. In conclusion, preoperative administration of parecoxib could effectively reduce postoperative pain, and postoperative analgesic consumption, and promote recovery after cervical laminoplasty.

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Cite the Article:

Guo X, Zhao R, Zhou J, Xue Y. Preoperative Administration of Parecoxib for Postoperative Pain Management in Cervical Laminoplasty: A Retrospective Study. World J Surg Surgical Res. 2022; 5: 1366.