Hemophagocytic Lymphohistiocytosis Revealing Prostate Adenocarcinoma: A Case Report

Dergaoui H, Barkat K, Al Awati M, Yahyaoui H, Ait Ameur M and Chakour M

Hematology Laboratory, Avicenne Military Hospital, Marrakech, Morocco

^*Correspondance to: Dergaoui Hanane 

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Abstract:

Hemophagocytic Lymphohistiocytosis (HLH) is a state of hyperinflammation resulting from an overproduction of pro-inflammatory cytokines, leading to the activation of macrophages that ingest the blood components (red blood cells, leukocytes, platelets). HLH is categorized into primary and secondary forms. Primary HLH is associated with a primary immune deficiency, while secondary HLH is related to various pathological conditions, including neoplastic diseases, infections, and autoimmune diseases. Solid tumors are rarely associated with HLH, accounting for only 1% of cases, mainly in the presence of bone marrow metastases, a relationship that is seldom documented in the literature through isolated cases. We report here a case of HLH revealing prostate cancer with bone marrow metastasis in a 58-year-old patient. HLH is a serious condition with a high mortality rate, due to an inappropriate immune response. Targeted etiological treatment is essential and may be effective in certain situations.

Keywords:

Hemophagocytic lymphohistiocytosis; Prostate adenocarcinoma; AST

Cite the Article:

Dergaoui H, Barkat K, Al Awati M, Yahyaoui H, Ait Ameur M, Chakour M. Hemophagocytic Lymphohistiocytosis Revealing Prostate Adenocarcinoma: A Case Report. World J Surg Surgical Res. 2024; 7: 1570..