Serum Fat-Soluble Vitamin Levels in Patients with Hip Fracture in Central China

Lou W, Zou K, Yu Z, Xiong R and Che B

Department of Orthopedics, General Hospital of the Yangtze River Shipping and Wuhan Brain Hospital, China

^*Correspondance to: Biao Che 

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Abstract:

Background: To investigate the relationship between fat-soluble vitamins and hip fracture, which is significant for the prevention and treatment of hip fracture. Method: The present study was a case-control analysis of hip-fracture patients (n=25) and non- fracture patients (n=32). The associations of fat-soluble vitamin (vitamin A, D, E and K) and other variables (such as Bone Mineral Density (BMD), disease status, BMI, age, sex, drinking, smoking) with hip fracture were investigated. Subgroup analysis based on vitamin D status were further emphatically investigated. Results: The mean serum level of 25(OH)D3 (10.9 ± 4.62 ng/mL) and 25(OH)D (12.5 ± 4.91 ng/ mL) for the hip fracture group was significantly lower than that of 25(OH)D3 (17.6 ± 7.63 ng/ mL, P<0.001) and 25(OH)D (19.5 ± 7.71 ng/mL, P<0.001) for the controls. A low vitamin A level (P<0.001) was also demonstrated in hip fracture patients (309 ± 115 ng/mL) in comparison with the controls (468 ± 138 ng/mL), but no significant differences were found in vitamin E and vitamin K1. It was found that BMD and 25(OH)D level were final high-risk factors of hip fracture. In subgroup analysis of vitamin D status, 92.0% of the hip-fracture group has deficient or insufficient serum 25(OH)D concentrations, significantly higher than the control group. Besides 25(OH)D3, significant differences in vitamin A (P<0.001) and vitamin K1 (P=0.01) were found among subgroups. Conclusion: It is found that although insufficiency or deficiency of 25(OH)D and a decrease BMD with osteopenia or osteoporosis are high risk factors of hip fracture, the insufficiency of other fat- soluble vitamins likely plays a role in hip fracture. The proper supplement is favor for reduced risk of hip-fracture.

Keywords:

Vitamin D; Fat-soluble vitamin; Bone mineral density; Hip fracture

Cite the Article:

Lou W, Zou K, Yu Z, Xiong R, Che B. Serum Fat-Soluble Vitamin Levels in Patients with Hip Fracture in Central China. World J Surg Surgical Res. 2023; 6: 1516..