Association of Lymphocytes with the Duration of Survival in Artificially Fed Patients with Dysphagia: A Retrospective Cohort Study

Qingzhi Song, Er-bao Chen, Dong Huang and Guoqing Lv

Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital and Anhui Medical University, PR China Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, PR China Department of Hepato-Pancreato-Biliary Surgery, Peking University Shenzhen Hospital, PR China

^*Correspondance to: Guoqing Lv 

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Abstract:

Background: Malnutrition and survival in hospitalized patients in previous research, the relation between total lymphocyte is an indicator of malnutrition of blood, however, the correlation between lymphocytes and hospitalized patients survival of scientific papers is less, and this study was to explore the blood total lymphocyte and artificial feeding of the relations between the patients with dysphagia survival. Methods: This study was a single-center retrospective cohort study. Data from a Japanese hospital: The study examined the long-term outcomes of elderly patients with dysphagia who received percutaneous endoscopic gastrostomy or total parenteral nutrition between January 2014 and January 2017. There were 253 patients, and the main outcome was survival time. Result: In multiple regressions, after adjusting potential confounders, it was found that for every additional unit of total lymphocytes in the blood, the survival risk ratio of patients decreased by 4%. The effect was more significant in the sensitivity analysis. The non-linear relationship between the total number of lymphocytes in the blood and the survival of patients was detected in the curve fitting, and the inflection point was 19.94 × 102/mm3. The effect size and confidence interval on the left and right sides of the inflection point were 0.92 (0.88 ~ 0.96) P<0.0001 and 1.02 (0.98 ~ 1.07) P=0.2882, respectively. Conclusion: The relationship between total lymphocytes and survival of patients with dysphagia who received artificial feeding is non-linear. When total lymphocytes <19.94 × 102/mm3, the increase of total lymphocytes may lead to the extension of patient survival.

Keywords:

Dysphagia; Artificial nutrition; Total lymphocytes; Total parenteral nutrition; Percutaneous endoscopic gastrostomy

Cite the Article:

Song Q, Chen E-B, Huang D, Lv G. Association of Lymphocytes with the Duration of Survival in Artificially Fed Patients with Dysphagia: A Retrospective Cohort Study. World J Surg Surgical Res. 2022;5:1375..