Journal Basic Info

  • Impact Factor: 1.989**
  • H-Index: 6
  • ISSN: 2637-4625
  • DOI: 10.25107/2637-4625
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Colorectal Surgery
  •  Cardiac Surgery
  •  Anesthesiology
  •  Trauma Surgery
  •  Ophthalmology & Eye Surgery
  •  Podiatric Surgery
  •  Spine Surgery
  •  Reconstructive Surgery

Abstract

Citation: World J Surg Surg Res. 2022;5(1):1401.DOI: 10.25107/2637-4625.1401

Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Prognostic Nutrition Index in Patients with Non- Small Cell Lung Cancer Receiving Pulmonary Resection

Motono N, Mizoguchi T, Ishikawa M, Iwai S, Iijima Y and Uramoto H

Department of Thoracic Surgery, Kanazawa Medical University, Japan

*Correspondance to: Nozomu Motono 

 PDF  Full Text Research Article | Open Access

Abstract:

Background: The prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) and Prognostic Nutritional Index (PNI) for patients with early-stage Non-Small Cell Lung Cancer (NSCLC) has not been elucidated. In the present study, we retrospectively evaluated the prognostic value of NLR and PNI for patients with NCSLC received pulmonary resection, even early-stage patients. Materials and Methods: The clinical data of 739 patients who underwent pulmonary resection for NSCLC were collected, and the prognostic value of NLR and PNI were analyzed. Results: Coexistence of Interstitial Lung Disease (ILD) (p<0.01), coexistence of arrhythmia (p=0.04), smoking status (p=0.02), Carcinoembryonic Antigen (CEA) (p=0.04), NLR>1.75 (p=0.01), and pathological stage (p<0.01) were revealed as significant factors for Progression Free Survival (PFS) in the multivariate analysis. Coexistence of ILD (p=0.03), smoking status (p<0.01), CEA (p<0.04), PNI<47.97 (p=0.01), and pathological stage (p<0.01) were revealed as significant factors for overall survival in the multivariate analysis. Furthermore, smoking status (p=0.01), CEA (p=0.03), NLR>4.04 (p<0.01), pathological stage (p=0.01), and lobectomy (p<0.01) were revealed as significant factors for PFS in pathological stage I NSCLC patients. Smoking status (p<0.01), PNI<49.19 (p=0.02), pathological stage (p=0.01), and wedge resection (p=0.01) were revealed as significant factors for OS in pathological stage I NSCLC patients. Conclusion: NLR was revealed as the significant factor for PFS in NSCLC patients received surgical treatment, even patients with pathological stage I. Furthermore, PNI was revealed as a significant factor of OS for NSCLC patients received surgical treatment.

Keywords:

Neutrophil-to-lymphocyte ratio; Prognostic nutritional index; Non-small cell lung cancer; Surgery

Cite the Article:

Motono N, Mizoguchi T, Ishikawa M, Iwai S, Iijima Y, Uramoto H. Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Prognostic Nutrition Index in Patients with Non-Small Cell Lung Cancer Receiving Pulmonary Resection. World J Surg Surgical Res. 2022; 5: 1401..

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