World J Surg Surg Res | Volume 5, Issue 1 | Research Article | Open Access

Detection of Human Cytomegalovirus by Clinical Metagenomics in a Non-Healing Wound of Recurrent Malignant Tenosynovial Giant Cell Tumor

Yang WT¹, Chiang I², Lai CS³, Mao Y^4,5, Lai KL⁶, Tseng CH¹, Liu CW¹, Huang YT^7* and Liu PY^1,8,9,*

¹Department of Internal Medicine, Division of Infection, Taichung Veterans General Hospital, Taiwan
²Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taiwan
³Department of Surgery, Division of Plastic and Reconstructive Surgery, Taichung Veterans General Hospital, Taiwan
⁴Department of Emergency Medicine, Division of Clinical Toxicology, Taichung Veterans General Hospital, Taiwan
⁵School of Medicine, National Defense Medical Center, Taiwan
⁶Department of Internal Medicine, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General
Hospital, Taiwan
⁷Department of Computer Science and Information Engineering, National Chung Cheng University, Taiwan
⁸Translational Medicine, National Chung Hsing University, Taiwan
⁹Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taiwan

^*Correspondance to: Yao-Ting Huang 

Abstract

Clinical metagenomic next-generation sequencing is an emerging approach for identifying pathogens of various infectious diseases. We present a case with a malignant tenosynovial giant cell tumor and chronic non-healing wound. Metagenomic next-generation sequencing of wound tissue biopsy identified Cytomegalovirus. Tumor recurrence over the previous non-healing wound was found three months later. The literature regarding CMV infection and tumorigenesis, the pathogenesis of malignant tenosynovial giant cell tumor, and the application of metagenomics in oncology are also reviewed herein.

Keywords:

Cytomegalovirus infections; Metagenomics; High-throughput nucleotide sequencing; Giant cell tumor of tendon sheath

Citation:

Yang WT, Chiang I, Lai CS, Mao Y, Lai KL, Tseng CH, et al. Detection of Human Cytomegalovirus by Clinical Metagenomics in a Non-Healing Wound of Recurrent Malignant Tenosynovial Giant Cell Tumor. World J Surg Surgical Res. 2022; 5: 1426.