Detection of Human Cytomegalovirus by Clinical Metagenomics in a Non-Healing Wound of Recurrent Malignant Tenosynovial Giant Cell Tumor

Yang WT, Chiang I, Lai CS, Mao Y, Lai KL, Tseng CH, Liu CW, Huang YT and Liu PY

Department of Internal Medicine, Division of Infection, Taichung Veterans General Hospital, Taiwan
Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taiwan
Department of Surgery, Division of Plastic and Reconstructive Surgery, Taichung Veterans General Hospital, Taiwan
Department of Emergency Medicine, Division of Clinical Toxicology, Taichung Veterans General Hospital, Taiwan
School of Medicine, National Defense Medical Center, Taiwan
Department of Internal Medicine, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General
Hospital, Taiwan
Department of Computer Science and Information Engineering, National Chung Cheng University, Taiwan
Translational Medicine, National Chung Hsing University, Taiwan
Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taiwan

^*Correspondance to: Yao-Ting Huang 

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Abstract:

Clinical metagenomic next-generation sequencing is an emerging approach for identifying pathogens of various infectious diseases. We present a case with a malignant tenosynovial giant cell tumor and chronic non-healing wound. Metagenomic next-generation sequencing of wound tissue biopsy identified Cytomegalovirus. Tumor recurrence over the previous non-healing wound was found three months later. The literature regarding CMV infection and tumorigenesis, the pathogenesis of malignant tenosynovial giant cell tumor, and the application of metagenomics in oncology are also reviewed herein.

Keywords:

Cytomegalovirus infections; Metagenomics; High-throughput nucleotide sequencing; Giant cell tumor of tendon sheath

Cite the Article:

Yang WT, Chiang I, Lai CS, Mao Y, Lai KL, Tseng CH, et al. Detection of Human Cytomegalovirus by Clinical Metagenomics in a Non-Healing Wound of Recurrent Malignant Tenosynovial Giant Cell Tumor. World J Surg Surgical Res. 2022; 5: 1426.