World J Surg Surg Res | Volume 5, Issue 1 | Research Article | Open Access
Yang WT1, Chiang I2, Lai CS3, Mao Y4,5, Lai KL6, Tseng CH1, Liu CW1, Huang YT7* and Liu PY1,8,9,*
1Department of Internal Medicine, Division of Infection, Taichung Veterans General Hospital, Taiwan
2Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taiwan
3Department of Surgery, Division of Plastic and Reconstructive Surgery, Taichung Veterans General Hospital, Taiwan
4Department of Emergency Medicine, Division of Clinical Toxicology, Taichung Veterans General Hospital, Taiwan
5School of Medicine, National Defense Medical Center, Taiwan
6Department of Internal Medicine, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General
7Department of Computer Science and Information Engineering, National Chung Cheng University, Taiwan
8Translational Medicine, National Chung Hsing University, Taiwan
9Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taiwan
*Correspondance to: Yao-Ting HuangFulltext PDF
Clinical metagenomic next-generation sequencing is an emerging approach for identifying pathogens of various infectious diseases. We present a case with a malignant tenosynovial giant cell tumor and chronic non-healing wound. Metagenomic next-generation sequencing of wound tissue biopsy identified Cytomegalovirus. Tumor recurrence over the previous non-healing wound was found three months later. The literature regarding CMV infection and tumorigenesis, the pathogenesis of malignant tenosynovial giant cell tumor, and the application of metagenomics in oncology are also reviewed herein.
Cytomegalovirus infections; Metagenomics; High-throughput nucleotide sequencing; Giant cell tumor of tendon sheath
Yang WT, Chiang I, Lai CS, Mao Y, Lai KL, Tseng CH, et al. Detection of Human Cytomegalovirus by Clinical Metagenomics in a Non-Healing Wound of Recurrent Malignant Tenosynovial Giant Cell Tumor. World J Surg Surgical Res. 2022; 5: 1426.