Safety and Biochemical Impact of Cyanoacrylate-Based Sealant GLUBRAN® 2 on Postoperative Drainage Fluids after Breast Surgery: A Randomized Controlled Trial

Emanuela Esposito, Renato de Falco, Claudio Siani, Sergio Arpino, Denise Giannascoli, Luigi Russo, Ernesta Cavalcanti and Raimondo di Giacomo

SC Chirurgia Oncologica di Senologia, Istituto Nazionale Tumori – IRCCS – Fondazione “G. Pascale”, Naples, Italy SC Medicina di Laboratorio, Istituto Nazionale Tumori – IRCCS – Fondazione “G. Pascale”, Naples, Italy Scuola di Specializzazione in Patologia Clinica e Biochimica Clinica, Università degli Studi di Napoli Federico II, Naples, Italy These authors contributed equally to this work

^*Correspondance to: Emanuela Esposito 

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Abstract:

Seroma and lymphocele often occur amongst patients after breast surgery and axillary lymphadenectomy, increasing postoperative morbidity and delaying adjuvant therapy. Cyanoacrylate-based sealants, such as Glubran® 2, have been proposed to reduce seroma formation, though evidence remains inconsistent. In order to evaluate the effect on human body fluids, drainage fluids were collected from 80 patients (38 treated with Glubran® 2 and 42 controls) on the day of drain removal (15 days post-surgery). All biochemical and cytological parameters analyzed showed no statistically significant differences between the Glubran® 2 and control groups. Interleukin-6 concentrations were elevated in both groups, exceeding normal reference values, indicating a sustained local inflammatory response. Glubran® 2 appears to be safe for use in breast of postoperative drainage fluids. The persistent inflammatory profile suggests that seroma formation is primarily driven by surgical trauma rather than the sealant’s presence.

Keywords:

Breast cancer; Seroma; Cyanoacrylate glue; Glubran® 2; Drainage

Cite the Article:

Esposito E, de Falco R, Siani C, Arpino S, Giannascoli D, Russo L, et al. Safety and Biochemical Impact of Cyanoacrylate-Based Sealant GLUBRAN® 2 on Postoperative Drainage Fluids after Breast Surgery: A Randomized Controlled Trial. World J Surg Surgical Res. 2026; 9: 1612..