Effects of Daikenchuto, a Traditional Japanese Herbal Medicine, after Laparoscopic Sacrocolpopexy for Pelvic Organ Prolapse: A Randomized, Single-Center, Open- Label Trial

Sato H, Okumura Y, Otsuka S, Abe H and Tsukada S

Department of Urology, Hokusuikai Kinen Hospital, Ibaraki, Japan Department of Pharmacy, Hokusuikai Kinen Hospital, Ibaraki, Japan Department of Urology, Kameda Medical Center, Chiba, Japan Department of Orthopedic Surgery, Hokusuikai Kinen Hospital, Ibaraki, Japan

^*Correspondance to: Hirotaka Sato 

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Abstract:

Background: This study evaluated the efficacy and safety of Daikenchuto (DKT) for Japanese female patients who required Laparoscopic Sacrocolpopexy (LSC) for symptomatic pelvic organ prolapse. Methods: This prospective, 1-week, two-arm, parallel-group, open-label, single-center randomized trial was conducted between June 2020 and February 2024. The primary endpoint was the time from surgery completion to the first bowel movement. Secondary endpoints were the time from surgery completion to the first flatus, time from surgery completion to solid food toleration, dissatisfaction attributable to constipation, distension, and changes in serum white blood cell counts and C-reactive protein levels. Results: The time from surgery completion to the first bowel movement of the DKT group (mean, 58.4 h; Standard Error [SE], ± 2.84 h) and that of the control group (66.1 h; SE, ± 2.63 h) were statistically significant (P=0.047). The change in the visual analog scale score for dissatisfaction attributable to constipation of the DKT group (estimated difference, –5.59; SE, ± 2.66; 95% Confidence Interval [CI], 19.5-26.8) and that of the control group (95% CI, 25.0-32.5) were statistically significant (P=0.037). Adverse events attributable to DKT were not observed. Conclusion: DKT accelerated the onset of intestinal movement and reduced dissatisfaction attributable to constipation.

Keywords:

Daikenchuto; Minimally invasive sacrocolpopexy; Bowel movement

Cite the Article:

Sato H, Okumura Y, Otsuka S, Abe H, Tsukada S. Effects of Daikenchuto, a Traditional Japanese Herbal Medicine, after Laparoscopic Sacrocolpopexy for Pelvic Organ Prolapse: A Randomized, Single-Center, Open-Label Trial. World J Surg Surgical Res. 2024; 7: 1572..