Bacterial DNA Translocation in Children with Congenital Heart Disease Undergoing Cardiopulmonary Bypass

Ge J, Wan PJ, Jin L, Shen L and Deng D

Department of Dermatology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, China Department of Cardiothoracic Surgery, Shanghai Children’s Hospital, Children’s Hospital of Shanghai Jiao Tong University, China

^*Correspondance to: Dan Deng 

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Abstract:

Background: Cardiopulmonary Bypass (CPB) is a routine clinical practice in cardiac surgery, however, CPB can result in bacterial DNA (bactDNA) translocation and endotoxemia. We aimed to detect the incidence, risk factors and the effect of the bactDNA translocation on postoperative outcomes in children with Congenital Heart Disease (CHD) after CPB. Methods: Children with CHD who underwent CPB between March 2017 and May 2017 were identified. General and postoperative outcome-related information was retrieved. Intestinal Fatty Acid Binding Protein (IFABP) level was detected, the data were compared between patients with and without bactDNA translocation. Results: The median length of CPB was 71.5 (53-102) minutes vs. 53 (45-65) minutes in patients with and without bactDNA in their blood (p=0.004). The median aortic cross-clamp time was 45 (30-61.5) minutes vs. 31 (23-36.5) minutes in patients with or without bactDNA in their blood (p=0.017). A higher postoperative level of IFABP (p=0.038) was identified in patients with bcatDNA translocation. Postoperative Mechanical ventilation time (p=0.004), ICU stay (p=0.008) and hospital stay (p=0.003) were all longer in patients with bactDNA translocation. The incidence of early complication was higher in patients with bactDNA translocation (p=0.000). Conclusion: Intestinal damage is frequent after pediatric congenital heart surgery. BactDNA translocation into the blood increases increase the incidence of postoperative adverse outcome in children with CHD who undergo CPB.

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Cite the Article:

Ge J, Wan PJ, Jin L, Shen L, Deng D. Bacterial DNA Translocation in Children with Congenital Heart Disease Undergoing Cardiopulmonary Bypass. World J Surg Surgical Res. 2024; 7: 1561..