The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

Song W, He J, Wu X, Su M, Hu R and Zhao Y

Department of Human Histology and Embryology, Guizhou Medical University, China Characteristic Key Laboratory of Translational Medicine Research of Cardiovascular and Cerebrovascular Diseases in Guizhou Province, Guizhou Medical University, China Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Regenerative Medicine in Guizhou Province, Guizhou Medical University, China These authors contributed equally to this work

^*Correspondance to: Rong Hu 

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Abstract:

Cholesterol and its metabolites play a crucial role in cancer development and suppression of immune responses. In recent years, a large number of experimental and clinical studies have shown that manipulation of cholesterol metabolism modulates functions in tumor biological processes, particularly oncogenic signaling pathways, ferroptosis, and the tumor microenvironment. We elucidate in detail the interactive effects produced by cholesterol metabolism and the tumor microenvironment. We also discuss therapeutic strategies aimed at interfering with cholesterol metabolism, and some new cholesterol metabolizing molecules, SREBP, SQLE and HMGCR have recently emerged as promising drug targets for cancer therapy. Here, we systematically review the role of cholesterol and its metabolites, as well as recent advances in cancer therapy targeting cholesterol metabolism.

Keywords:

Cholesterol; Metabolism; Cancer; Tumor Microenvironment; Immune

Cite the Article:

Song W, He J, Wu X, Su M, Hu R, Zhao Y. The Role of Cholesterol Metabolism and Its Regulation in Tumor Development. World J Surg Surgical Res. 2024; 7: 1538..