Comparative Assessment of Vessel Reactivity in Medication-Related Osteonecrosis of the Jaw

Kosach German A

Department of Dentistry and Maxillofacial Surgery, Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation, Russia

^*Correspondance to: German Alexandrovich Kosach 

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Abstract:

Anti-osteoclastic-Associated Osteonecrosis of the Jaw (AAOJ) is a condition associated with the use of antiresorptive drugs, such as RANKL inhibitors (monoclonal antibody-denosumab), nitrogen-containing bisphosphonates (zoledronic acid), and the use of some narcotic phosphatecontaining substances (desomorphine). It manifests as a persisting (more than 8 weeks) open wound surface of the jaw bone tissue after dental surgical intervention. Currently, AAOJ is widely discussed in the scientific and clinical community. Since the first description of the disease [1], clinicians and scientists have been focused on identifying its mechanisms of occurrence. The main theories of AAOJ development include: Immune regulation disorders and excessive inflammation [2], accelerated apoptosis of osteoblasts and osteocytes [3], secondary infection [4], microvascular damage [1,5].

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Cite the Article:

Kosach German A. Comparative Assessment of Vessel Reactivity in Medication-Related Osteonecrosis of the Jaw. World J Surg Surgical Res. 2024; 7: 1537..