Fibrinogen is an Independent Preoperative Predictor of Hospital Length of Stay among Patients Undergoing Coronary Artery Bypass Grafting

Wenyuan Zhang1,2, Xiaojie Liu1 , Lijuan Wang1 , Sudena Wang1 , Yang Yu1 and Hushan Ao1 *

1Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, China 2Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, China

^*Correspondance to: Hushan Ao 

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Abstract:

Objective: This study aimed to explore the effects of preoperative fibrinogen concentration on outcomes of patients undergoing Coronary Artery Bypass Grafting (CABG) over a short- term period and hospital Length of Stay (LOS). Methods: A retrospective study included 936 patients who consecutively underwent isolated, primary off-pump or on-pump CABG between December 2017 and November 2018. Preoperative fibrinogen concentration, baseline index, intraoperative data, duration of Intensive Care Unit (ICU) stay and LOS were recorded. The prime endpoint was LOS. Univariate and multiple linear regressions were used to evaluate the correlation between preoperative fibrinogen concentration and LOS. Results: Preoperative variables that independently shortened the likelihood of LOS was preoperative fibrinogen concentration (B=0.073, P=0.04); a significant shorten in likelihood was found with High Hemoglobin (HGB) (B= -0.140, P<0.001). Preoperative variables that significantly decreased the likelihood of duration of ICU stay was Male gender (B= -0.092, P=0.02). Like Plateletcrit (PCT) (B= -0.121, P<0.001), preoperative fibrinogen concentration (B= -0.073, P=0.03) was also associated with postoperative bleeding volume. Conclusion: Fibrinogen is an independent preoperative predictor of LOS and postoperative bleeding volume. Patients with low preoperative fibrinogen concentration lost more blood and had longer LOS. Male gender was association with shorter duration of ICU stay and preoperative higher HBG was association with longer LOS.

Keywords:

Fibrinogen; Hospital length of stay; Coronary artery bypass grafting; Bleeding

Cite the Article:

Zhang W, Liu X, Wang L, Wang S, Yu Y, Ao H. Fibrinogen is an Independent Preoperative Predictor of Hospital Length of Stay among Patients Undergoing Coronary Artery Bypass Grafting. World J Surg Surgical Res. 2022; 5: 1367..