Journal Basic Info

  • Impact Factor: 1.989**
  • H-Index: 6
  • ISSN: 2637-4625
  • DOI: 10.25107/2637-4625
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Spine Surgery
  •  Robotic Surgery
  •  Hand Surgery
  •  Minimal Invasive Surgery
  •  Obstetrics & Gynecology
  •  Cardiovascular Surgery
  •  Breast Surgery
  •  Pediatric Surgery

Abstract

Citation: World J Surg Surg Res. 2022;5(1):1364.DOI: 10.25107/2637-4625.1364

Clinical Efficacy of Radiotherapy Combined with Surgery for Locally Advanced Gastric Signet-Ring-Cell Carcinoma

Xiaohan Lin, Biyu Chen, Wei Zheng, Shugang Yang, Guangwei Zhu, Jinzhou Wang, Yongjian Huang* and Jianxin Ye*

Department of Gastrointestinal Surgery Section 2, the First Affiliated Hospital of Fujian Medical University, China

*Correspondance to: Jianxin Ye 

 PDF  Full Text Research Article | Open Access

Abstract:

he Incidence of Gastric Signet-Ring-Cell Carcinoma (GSRCC) is increasing yearly. However, the effectiveness of strategies for treatment of GSRCC patients remains ambiguous. This study was aimed to assess the clinical efficacy of radiotherapy combined with surgery for locally advanced Gastric Signet-Ring-Cell Carcinoma (GSRCC). Clinical data of patients with locally advanced GSRCC diagnosed by postoperative pathology from 2000 to 2016 were collected from the US Surveillance, Epidemiology and End Results (SEER) database. All the enrolled patients were divided into three groups according to treatment type: Surgery alone (S; N=727), surgery with preoperative radiotherapy (RT+S; N=138), surgery with postoperative radiotherapy (S+RT; N=548). It was found that the median Overall Survival (OS) time in S, RT+S and S+RT group was 19, 26 and 33 months, respectively; the Overall Survival (OS) rate was 19.5%, 26.9% and 34.0%, respectively; the median Cancer-Specific Survival (CSS) time was 29, 31 and 43 months, respectively; and the CSS rate was 32.4%, 35.3% and 43.6%, respectively. After performing Propensity Score Matching (PSM), it was found that the OS rate was significantly lower in S group than in RT+S or S+RT group (all P<0.05) and the CSS rate was lower in the S group than in the S+RT group (P<0.0001) while there was no significant difference between S and RT+S groups. The OS and CSS were not significantly different between RT+S and S+RT groups. Cox multivariate analysis showed that radiotherapy was an independent prognostic factor for OS and CSS of locally advanced GSRCC. Taken together, compared to surgery alone, surgery combined with preoperative or postoperative radiotherapy is beneficial to the long-term survival of patients with locally advanced GSRCC.

Keywords:

Gastric signet-ring-cell carcinoma; Radiotherapy; Surgical therapy; Clinical efficacy

Cite the Article:

Lin X, Chen B, Zheng W, Yang S, Zhu G, Wang J, et al. Clinical Efficacy of Radiotherapy Combined with Surgery for Locally Advanced Gastric SignetRing-Cell Carcinoma. World J Surg Surgical Res. 2022; 5: 1364..

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