Role of SPC24 Expression in Glioblastoma based on Oncomine and GEO Database

Xinjie Ning, Juncheng Luo, Gengqiang Ling, Xiaochun Zhong and Binchu Xu

Department of Neurosurgery, Sun Yat-Sen University, China

^*Correspondance to: Binchu Xu 

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Abstract:

Background: Glioblastoma (GBM) is one of the malignant tumors causing death worldwide. Most of the patients were found in the middle and late stages with poor prognosis. The purpose of this study was to investigate the expression and significance of SPC24 in GBM.
Methods: The information about SPC24 in Oncomine database was collected, and the data in current database were calculated by secondary analysis. The role of SPC24 in GBM was meta-analyzed. The expression of SPC24 in glioma cell lines was retrieved by CCLE database, and the survival of patients was analyzed via GEO database.
Results: A total of 792 different types of SPC24 were collected in Oncomine database. Among them, 38 studies showed statistical differences in the expression of SPC24, 24 studies showed increased expression of SPC24 and 14 studies showed decreased expression. Four studies involving the expression of SPC24 in GBM cancer and normal tissues included 1,189 samples. Compared with the control group, SPC24 was highly expressed in GBM (P<0.05). Moreover, SPC24 was highly expressed in glioma cell lines. There was a correlation between the expression of SPC24 and the overall survival rate of GBM. The overall survival rate of patients with high expression of SPC24 was worse, while the prognosis of patients with low expression of SPC24 was better (P<0.05).
Conclusion: Through in-depth mining of oncomine gene chip database and GEO, we demonstrate that SPC24 is highly expressed in GBM tissues and is related to the prognosis of GBM, which may provide an important theoretical basis for the treatment of GBM.

Keywords:

SPC24; Glioblastoma; Oncomine; Geo

Cite the Article:

Ning X, Luo J, Ling G, Zhong X, Xu B. Role of SPC24 Expression in Glioblastoma based on Oncomine and GEO Database. World J Surg Surgical Res. 2019; 2: 1131.