Journal Basic Info
- Impact Factor: 1.989**
- H-Index: 6
- ISSN: 2637-4625
- DOI: 10.25107/2637-4625
Major Scope
- Neurological Surgery
- Laparoscopic Surgery
- Cardiovascular Surgery
- Anesthesiology
- Dental Surgery
- Transplant Surgery
- Urological Surgery
- Surgical Oncology
Abstract
Citation: World J Surg Surg Res. 2019;2(1):1124.DOI: 10.25107/2637-4625.1124
Paraneoplastic Syndrome May be a Favorable Prognostic Factor in Patients with Hepatocellular Carcinoma Following Hepatectomy
Xu-Zhuo Feng, Jian-Hong Zhong, Ya-Peng Qi, Teng Wei, Bang-De Xiang, Wei-ping Yuan and Le-Qun Li
Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, China
Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center, China
*Correspondance to: Bang-De Xiang
PDF Full Text Research Article | Open Access
Abstract:
Background: It is unclear whether the presence of Paraneoplastic Syndromes (PNS) affect prognosis of patients with Hepatocellular Carcinoma (HCC) after surgical resection.
Methods: In our study, 1,446 HCC patients at our hospital with or without PNS were analyzed. Survival was compared between the two groups of patients using Kaplan-Meier analysis and the log-rank test, and Cox proportional hazards modeling was used to identify independent predictors of prognosis. Analyses were performed for the entire patient population as well as for propensity score-matched patients with or without PNS.
Results: Of the 1,446 HCC patients, 271 (18.7%) patients presented PNS. Patients with PNS were older and had larger tumors and higher levels of Alpha-Fetoprotein (AFP) than those without PNS. Post-resection survival rate was lower among patients with PNS than those without PNS. Before matching, the survival time of the patients with hypoglycemia was worse than the patients without PNS, and there was no significant difference between the prognosis of the patients with erythrocytosis/thrombocytosis and the patients without PNS. After matching, the survival time of the patients with erythrocytosis was better than the patients without PNS, and there was no significant difference between the prognosis of the patients with hypoglycemia/thrombocytosis and the patients without PNS. Multivariate analysis showed that Barcelona Clinic Liver Cancer stage C and tumor diameter >10 cm were independent predictors of poor prognosis, while PNS and erythrocytosis were independent predictors of better prognosis.
Conclusion: After adjusting for potential effects, prognosis is better for HCC patients with PNS than those patients without PNS.
Keywords:
Hepatocellular carcinoma; Paraneoplastic syndromes; Prognosis
Cite the Article:
Feng X-Z, Zhong J-H, Qi Y-P, Wei T, Xiang B-D, Yuan W-P, et al. Paraneoplastic Syndrome May be a Favorable Prognostic Factor in Patients with Hepatocellular Carcinoma Following Hepatectomy. World J Surg Surgical Res. 2019; 2: 1124.