Immunological Changes Observed in ICH

Rajendra Shrestha, Reeka Pradhan and Chao You

Department of Neurosurgery, NAMS, Bir Hospital, Nepal
Paropkar Maternity and Women’s Hospital, Nepal
Department of Neurosurgery, West China Hospital, Sichuan University, China

^*Correspondance to: Rajendra Shrestha 

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Abstract:

Objective: Intracerebral Hemorrhage (ICH) is a one of the stroke subtype with high morbidity and mortality.
Aim: The aim of this prospective study was to assess immunological changes and their clinical significance in patients with ICH.
Method: Sixty patients with spontaneous ICH were evaluated regarding immunological changes by measuring peripheral blood lymphocytes subsets CD3+, CD4+, CD8+, CD4+/CD8+, white blood cell count, lymphocytes count and immunoglobin IgA, IgG, IgM, IgE and IgD level. The relationships of immunological to clinical and radiological parameters were evaluated at hospital admission (t0), 5 days (t1), and 10 days (t2). The results were statistically analyzed.
Result: Immunological parameters were significantly changes with severity of diseases. There were significant changes were observed for leucocyte count, lymphocytes sublets CD4, CD8, and CD4/ CD8 at hospital admission (t0), 5 days (t1), and 10 days (t2) in both operative and conservative patients. But there was not statistically significant in immunoglobin level. There were significant positive correlations between leukocyte with GCS (r=0.29, 0.30), Volume (r=0.55, 0.37) and mRS (r = -0.30, -0.47) during admission and discharge time respectively (p<0.05). But Leukocyte was negative correlation with CD4 at hospital admission (r = -0.80, -0.33) and discharge (r = -0.37, -0.45).There were negative correlations between CD 4 with GCS (r = -0.28, -0.34), volume of hematoma (r = -0.32, -0.56), mRS (r = -0.38, -0.46) during admission and discharge time (p<0.05).
Conclusion: Immunological parameters changes are associated with the severity of ICH. This may indicate potential goals for ICH therapy.

Keywords:

CD4+/CD8+; ICH; lymphocyte; WBC

Cite the Article:

Shrestha R, Pradhan R, You C. Immunological Changes Observed in ICH. World J Surg Surgical Res. 2019; 2: 1119.