Primary Non-Hodgkin Lymphoma of the Maxilla

Alexoudi Vaia-Aikaterini, Iskas Michail, Anagnostopoulos Achilles, Dimitriadis Ioannis and Antoniades Konstantinos

Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, Greece
Department of Hematology and BMT Unit, General Hospital of Thessaloniki, Greece
Department of Pathology, General Hospital of Thessaloniki “G. Papanicolaou”, Thessaloniki, Greece

^*Correspondance to: Antoniades Konstantinos 

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Abstract:

Lymphomas, or malignant lymphatic tissue neoplasms, can be classified as Hodgkin (HL) or NonHodgkin (NHL). Although head and neck lymphomas more frequently involve NHL, indicating extranodal proliferation, these cancers are relatively rare in the oral cavity. We report a case of a 56-year-old Caucasian woman who visited a dentist because of gradual buccal-side swelling near the upper left canine. The initial diagnosis was periapical abscess. She was later admitted to the department of Oral and Maxillofacial Surgery, Thessaloniki, Greece because of persistent swelling, where a diagnosis of primary NHL of the oral cavity was established following radiographic, histological and immunochemical studies. The patient was referred to the Department of Hematology, where she received R-CHOP therapy, concurrent intrathecal chemotherapy and subsequent involved field radiation therapy. After treatment completion, the findings of scheduled PET-CT restaging were consistent with a complete metabolic response. The patient continues to undergo regular follow-up CT scans and physical examinations. Our case experience suggests that each aggressive oral lesion should be screened to detect possible malignancy. An excisional biopsy and extensive histopathology evaluation should be performed prior to treatment initiation, and cooperation between hematologists and oral and maxillofacial surgeons is essential to early detection, diagnosis, and treatment and follow-up.

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Cite the Article:

Vaia-Aikaterini A, Michail I, Achilles A, Ioannis D, Konstantinos A. Primary Non-Hodgkin Lymphoma of the Maxilla. World J Surg Surgical Res. 2018; 1: 1045.