Topical Application of Adipose-Derived Mesenchymal Stem Cells in the Treatment of a Non-Healing Ulcer in a Leper: A Case Report - A New Option for Treatment of Extremely Chronic Ulcer

Lam PK, Winne Lo, Cindy SW Tong, Lo KY, Ping Chook, Paul BS Lai, Poon WS and Leung PC

Department of Surgery, Chinese University of Hong Kong, Hong Kong
Chow Tai Fook-Cheng Yu Tung Surgical Stem Cell Research Center, Chinese University of Hong Kong, Hong Kong
Institute of Chinese Medicine, Chinese University of Hong Kong, Hong Kong

^*Correspondance to: Leung PC 

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Abstract:

Neuropathic ulceration in the foot is one of the most serious complications in leprosy. The healing is much impaired because of chronic inflammation, deformation and neurological impairment. Current wound management protocols commonly fail to heal. The multipotency paracrine and immunomodulatory functions of Mesenchymal Stem Cells (MSC) enable them to offer a novel regenerative therapy to expedite the healing of lepromatous ulcer. In this case study, the 20 years chronic ulcer on the deformed foot of a leper healed after the left sole ulcer of a patient with a history of leprosy healed after topical application of expanded MSC. The ulcer had no recurrence up to 15 months after healing. No adverse defects were detected. The result of this pilot case is highly impressive. Experimental works to explore the mechanisms of healing are underway.

Keywords:

Stem cell; Non-healing ulcer; Topical application

Cite the Article:

Lam PK, Winne Lo, Cindy SW Tong, Lo KY, Ping Chook, Paul BS Lai, et al. Topical Application of Adipose-Derived Mesenchymal Stem Cells in the Treatment of a Non-Healing Ulcer in a Leper: A Case Report - A New Option for Treatment of Extremely Chronic Ulcer. World J Surg Surgical Res. 2018; 1: 1016.