Characteristics of the Trichophyton mentagrophytes F-01 Strain Used for the Manufacture of Biologics against Bovine Trichophyton

Abdiramanova BA, Umitzhanov M*, Imanbaev AA, Omarbekova GK and Bakirov NZ

Department of Obstetrics Surgery and Biotechnology of Reproduction, Kazakh National Agrarian Research University, Kazakhstan

^*Correspondance to: Umitzhanov M 

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Abstract:

According to the Committee on Statistics, there are 7,613.9 thousand heads of cattle in Kazakhstan. Currently, the fungal infection is widespread among agricultural and carnivorous animals. This infection has recently been found in an associated form. Therefore, the preservation of the wellbeing of various animal species and the improvement of existing vaccine preparations for the prevention and treatment of dermatomycosis (Trichophyton and Microsporum) of agricultural and carnivorous animals is a necessary condition for the development of small and large farm livestock farms in our country. Dermatomycosis infection of animals is on the list of particularly dangerous diseases, the prevention, diagnosis and elimination of which is carried out at the expense of budget funds. For the treatment and prevention of trichophytosis of animals in the Republic of Kazakhstan, expensive vaccine preparations imported from abroad were purchased through public procurement. Currently, we have developed a technology for manufacturing an improved domestic polyvalent inactivated vaccine against dermatomycosis of agricultural and carnivorous animals, which will solve the issues of prevention (treatment) of the disease, which will improve the epidemiological situation for dermatomycosis in the Republic of Kazakhstan, and ultimately will contribute to the production of safe animal products (milk, beef and leather raw materials) of high sanitary quality. Using the Trichophyton mentagrophytes F-01 vaccine strain, a domestic live and "Polyvalent inactivated vaccine against Trichophyton in agricultural and carnivorous animals" was developed. The vaccine strain Trichophyton mentagrophytes F-01 was obtained by step-by-step selection based on sporulation of fast-growing colonies with active accumulation of microconidia. The resulting vaccine strain differs from epizootic strains in weak virulence, high sporogenicity, and intramuscular activity. Currently, the highly immunogenic strain Trichophyton mentagrophytes F-01 is used for the manufacture of biological preparations against Trichophyton in farm animals.

Keywords:

Vaccine; Inactivation; Strain; Immunogenicity; Rabbits; Cattle

Cite the Article:

Abdiramanova BA, Umitzhanov M, Imanbaev AA, Omarbekova GK, Bakirov NZ. Characteristics of the Trichophyton mentagrophytes F-01 Strain Used for the Manufacture of Biologics against Bovine Trichophyton. World J Surg Surgical Res. 2022; 5: 1397..