Lin Han1, Yanjun Sun1, Zhuang Li2, Peng Zhang2 and Dengqun Sun1*
1Department of General Surgery, The Armed Police Corps Hospital of Anhui, China 2Graduate School, Anhui University of Chinese Medicine, ChinaFulltext PDF
Objectives: LAMA1 is expressed in a variety of tumors, but its role in rectal adenocarcinoma is not clear. This study was based on the Tumor Genome Map (TCGA) database to explore the relationship between LAMA1 and rectal adenocarcinoma. Materials and Methods: The patients with rectal adenocarcinoma were from TCGA. Wilcoxon rank sum test was used to compare the expression of LAMA1 in rectal adenocarcinoma and normal tissues. Wilcoxon rank sum test, Kruskal-Wallis test and logistic regression were used to analyze the relationship between LAMA1 and clinicopathological features. Cox regression and Kaplan-Meier methods were used to analyze the correlation between LAMA1 and survival rate. Besides, Gene Set Enrichment Analysis (GSEA) was used to investigate the biological functions of LAMA1. Results: Kaplan-Meier survival analysis showed that the Overall Survival rate (OS) of patients with high expression of LAMA1 was significantly higher than that of patients with low expression of LAMA1 (P=0.01). Univariate analysis showed that the low expression level of LAMA1 was associated with the deterioration of Overall Survival rate (OS) (P=0.010, HR=0.276 (95% CI [0.104- 0.733]). Multivariate analysis showed that LAMA1 was closely related to OS (P=0.026, HR=0.200 (95% CI [0.049-0.822]). GSEA shows that the high expression phenotype of LAMA1 has a significant enrichment effect on pathways in cancer, chemokine signaling pathway, IL18 signaling pathway, senescence and autophagy in cancer, T cell proliferation and regulation of cell morphogenesis. LAMA1 may be a prognostic indicator of low survival rate in patients with rectal adenocarcinoma. Conclusion: Decreased LAMA1 level may be a potential biomarker for diagnosis and prognosis of rectal adenocarcinoma. In addition, LAMA1 may be involved in the occurrence and development of rectal adenocarcinoma through chemokine signaling pathway and IL18 signaling pathway.
Rectal adenocarcinoma; LAMA1; Prognosis; TCGA; GSEA
Han L, Sun Y, Li Z, Zhang P, Sun D. LAMA1 is a Potential Molecule Associated with Poor Prognosis in Patients with Rectal Adenocarcinoma. World J Surg Surgical Res. 2022; 5: 1381..