Satoshi Hayama1,2*, Miri Fujita1, Naoto Senmaru1,2 and Satoshi Hirano2
1Department of Surgery, Steel Memorial Muroran Hospital, Japan
2Department of Gastroenterological Surgery, Hokkaido University Graduate School of Medicine, Japan
Background: Histopathological findings would impact the timing of early cholecystectomy, but
no reports have yet discussed. The aim of this study is to examine the feasible timing for early
cholecystectomy based on both conventional clinicopathological data and histopathological
Methods: We retrospectively analyzed 127 patients who underwent laparoscopic cholecystectomy
for AC at in our institutes between 2007 and 2012. Patients were categorized into two groups
according to the interval between surgery and symptom onset (early, ≤ 96 h; delayed, >96 h) for
comparison of clinical results. In addition, both histopathological findings and clinical results were
compared between the early group (≤ 96 h) and a sub-delayed subgroup of patients who underwent
cholecystectomy at >96 h but ≤ 240 h.
Results: No significant differences in surgical results were seen between the early group and delayed
group. In terms of histopathological findings, the sub-delayed subgroup showed significant phase
progression of cholecystitis compared to the early group. However, edema in the Gallbladder
(GB) wall was comparable in all cases operated on within 240 h, mirroring the lack of significant
differences in surgical results seen between early and sub-delayed subgroups.
Conclusion: Edema in the GB wall with AC is continuous within 10 days from onset, and emergency
laparoscopic cholecystectomy within this period is safe and feasible.
Acute cholecystitis; Cholecystectomy; Sub-delayed cholecystectomy; Histopathological findings; Edema in the gallbladder
Hayama S, Fujita M, Senmaru N, Hirano S. Evaluation of Early Cholecystectomy for Acute Cholecystitis within 10 Days of Onset, with Arguments based on Histopathological Findings. World J Surg Surgical Res. 2021; 4: 1320..