Journal Basic Info

  • Impact Factor: 1.989**
  • H-Index: 6
  • ISSN: 2637-4625
  • DOI: 10.25107/2637-4625
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Reconstructive Surgery
  •  Gastroenterological Surgery
  •  Urological Surgery
  •  Ophthalmology
  •  Hepatology
  •  Surgery & Surgical Research
  •  Surgical Procedures
  •  Cardiovascular Surgery

Abstract

Citation: World J Surg Surg Res. 2018;1(1):1025.DOI: 10.25107/2637-4625.1025

Synovial Fluid Analysis in Patients with Osteoarthritis Requiring Total Joint Arthroplasty

Elissa S. Davis, Christopher Wanderling, Daniel R. Schmitt, Jeffrey Liles, Kevin Galicia, Debra Hoppensteadt, Jawed Fareed and William Hopkinson

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, USA
Loyola University of Chicago, Stritch School of Medicine, Maywood, IL
Department of Pathology, Loyola University Medical Center, USA

*Correspondance to: Elissa S Davis 

 PDF  Full Text Research Article | Open Access

Abstract:

Background: Osteoarthritis (OA) is a progressive disease characterized by degeneration of the articular cartilage in joints. Currently, there are no preventative treatments available for OA, which has resulted in an increasingly heavy burden on the country’s healthcare system as the population continues to age. Despite the increasing emphasis on preventative health care overall in medicine, there have been minimal recent improvements in the prevention or management of OA.
Objective: To profile total protein content, CRP, IL-1b, MP-TF and PAI-1 in patients who suffer from OA that require total joint arthroplasty (TJA) procedure.
Method: Synovial fluid (SF) samples were taken perioperatively from 62 patients undergoing either total knee arthroplasty (TKA) or total hip arthroplasty (THA) procedures. The SF was then purified by centrifugation. Samples were aliquoted and stored at 80°C. Samples were analyzed for total protein by photo spectrometry and ELISA assays were used to analyze CRP, IL-1b, MP-TF and PAI-1 levels.
Results: The mean total protein load was 19.27 mg/ml ± 13.89 mg/ml. The mean values for these biomarkers were: CRP 1.54 ng/ml ± 1.86 ng/ml, IL-1b 0.19 pg/ml ± 0.18 pg/ml, MP-TF 14.17 pg/ml ± 19.94 pg/ml and PAI-1 19.87 ng/ml ± 6.29 ng/ml.
Conclusion: This novel study investigating the content of SF demonstrates that these biomarkers are present at detectable levels. These results may help better define the pathogenesis of OA and aid in the development of targeted therapies against the inflammatory pathway.

Keywords:

Osteoarthritis; Arthroplasty; Synovial fluid; Inflammation

Cite the Article:

Davis ES, Wanderling C, Schmitt DR, Liles J, Galicia K, Hoppensteadt D, et al. Synovial Fluid Analysis in Patients with Osteoarthritis Requiring Total Joint Arthroplasty. World J Surg Surgical Res. 2018; 1: 1025.

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